PhD students participating in August Krogh seminars receive 0,2 ECTS per seminar
AKC Double Seminar: Capillaries - Tiny Vessels, Big Impact: Unraveling Skeletal Muscle Blood Flow Regulation
Professor Emeritus Christopher G. Ellis
August Krogh Club Double Seminar
14:00-14:45: Coral Murrant: ”Rethinking Capillaries as Central to the Control of Tissue Blood Flow”.
14:45-15:30: Christopher G. Ellis: "Capillaries: the control center for matching oxygen supply to oxygen demand”.
15:30-16:30: Post seminar servings and socializing.
Capillaries: the control center for matching oxygen supply to oxygen demand
Christopher G. Ellis, Adjunct Research Scientist, Robarts Research Institute, Emeritus Professor, Department of Medical Biophysics, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
Abstract
Over 100 years ago, August Krogh, raised our awareness of the importance of capillaries in the delivery of oxygen to tissue and proposed that they could actively regulate capillary density in muscle. His achievement was remarkable given the limitations of the technology available to him at the time.
Following Krogh, much of the research on regulation of microvascular blood flow has focused on the arteriolar tree where numerous mechanisms govern the magnitude and distribution of red blood cells and plasma to the downstream capillary bed.
This presentation will return the spotlight to the role capillaries play in regulation of oxygen delivery; not as active regulators of capillary density but as the critical site for signaling the local oxygen needs of the muscle fascicle to guide the appropriate distribution of oxygen by the upstream arterioles. Insights gained from our newly reported capillary structure (the capillary fascicle) which supports the muscle fascicle lead to both a new understanding and new questions about the matching of oxygen supply to oxygen demand.
Research Profile
Dr Ellis is an Emeritus Professor in Medical Biophysics and an Adjunct Scientist in the Robarts Research Institute at The University of Western Ontario in Canada. He has been involved in microvascular research for the past 45 years.
His main focus has been on developing video microscopy technologies for studying oxygen transport in live animals with the goal of understanding how the microvasculature regulates the delivery of oxygen to match the metabolic demand of skeletal muscle.
He is also interested in any disease or condition that impairs this regulatory function and has worked with Critical Care Physicians to demonstrate the microvascular dysfunction occurs prior to the development of clinical symptoms. He is currently working on non-invasive approaches to detect impaired microvascular function.
Litterature
Venue
Auditorium 1, August Krogh Building, Universitetsparken 13, DK-2100 Copenhagen
Registration
Participation is free, but please register here.
For PhD students
PhD students participating in August Krogh seminars receive 0,2 ECTS per seminar
Contact
Kate Aiko Wickham, kawi@nexs.ku.dk
Jens Frey Halling, jefh@nexs.ku.dk
