PhD students participating in August Krogh seminars receive 0,2 ECTS per seminar
AKC Double Seminar: Small things, big impact: Small noncoding RNAs in human (patho)physiology
Associate Professor Yaël Nossent
August Krogh Club Double Seminar
14:00-14:45: Louise Torp Dalgaard: "Circulating and cellular microRNAs involved in metabolic disease”.
14:45-15:30: Yaël Nossent: ”The epitranscriptome; Small noncoding RNAs and their modifications in cardiovascular health and disease”.
15:30-16:30: Post seminar servings and socializing.
The epitranscriptome; Small noncoding RNAs and their modifications in cardiovascular health and disease
Associate Professor Yaël Nossent, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Abstract / Research Profile
I am a molecular biologist with a particular interest in the role of noncoding RNAs in the cardiovascular system. After completing my postdoc research at the University of Copenhagen and the University of Southern Denmark in Odense (DK), I moved to Leiden (NL) where I started a new research line on microRNAs in vascular remodeling.
My group was the first to describe a key role for microRNAs of the DLK1-DIO3 locus in vascular remodeling; in angiogenesis and arteriogenesis, but also in atherosclerosis, restenosis, and in arterial aneurysms. The DLK1-DIO3 locus also encodes other types of small noncoding RNAs however, including long noncoding RNAs (lncRNAs) and small nucleolar RNAs (snoRNAs). I am interested in how all these different RNAs influence the function of our blood vessels, during both health and disease.
However, RNA transcripts are not finished products. All RNAs undergo modifications, adding an important layer of regulation that can either (de-)stabilize an RNA, or even change its function. Strikingly, DLK1-DIO3 RNAs are among the most heavily modified RNAs, which affects their function in the cardiovascular system.
Modifications of RNAs in our bodies are directly affected by negative stimuli, such as stress or disease, but also for example by positive stimuli such as exercise. I recently moved to Copenhagen, where I aim to investigate how we can use exercise to optimize RNA modification profiles to lower the risk of cardiovascular events, such as acute stroke, in women of all ages.
Auditorium 1, August Krogh Building, Universitetsparken 13, DK-2100 Copenhagen
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