AKC seminar: Brown Fat in Human Metabolism

Camilla ScheeleAugust Krogh Seminar

Associate Professor Camilla Scheele

Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Denmark.

Abstract

Body fat distribution and adipocyte functionality are determinants of metabolic health in a depot-dependent fashion.

The ability to activate brown fat (BAT) in response to cold, associates with cardiometabolic health, whereas accumulation of lipids in the visceral adipose depot associates with cardiometabolic disease. The underlying mechanisms for these correlations remains elusive and motivates further comparisons of adipose depots in humans.

The prevalence of cold-activated BAT declines with age, whereas dormant BAT exist in most adults. Seasonal and individual differences suggest a plasticity in BAT activity and a potential for BAT reactivation. If BAT plays an active role in metabolic regulation, restoring this function could improve human metabolic health.

We are investigating the role of BAT secreted factors, so called batokines, in thermogenic differentiation as well as organ cross talk.

Literature

https://pubmed.ncbi.nlm.nih.gov/31638161/

https://pubmed.ncbi.nlm.nih.gov/35584644/

Time

26 May 2023

14:00-15:00: Seminar and discussion
15:00-16:00: Post seminar servings and socializing

Venue

Auditorium 1, August Krogh Building, Universitetsparken 13, DK-2100 Copenhagen

Registration

Participation is free, but please register here.

For PhD students

PhD students participating in August Krogh seminars receive 0,2 ECTS per seminar

Contact

Jens Frey Halling, jefh@nexs.ku.dk

Kate Aiko Wickham, kawi@nexs.ku.dk 

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