PhD students participating in August Krogh seminars receive 0,2 ECTS per seminar
AKC online seminar: Metabolic effects of growth hormone
August Krogh Club online seminar
Professor Jens Otto Lunde Jørgensen
The Department of Endocrinology and Diabetes, Aarhus University, Denmark.
Growth hormone (GH) is essential for postnatal longitudinal growth and mainly via stimulation of hepatic and peripheral formation of insulin-like growth factor I (IGF-I). In addition, GH potently and directly stimulates lipolysis and lipid oxidation.
The shift in action between protein anabolism and lipid catabolism is regulated by energy balance such that the postprandial state favors IGF-I activity, whereas short- and long term fasting suppresses IGF-I, which in turn feedback stimulates the secretion and direct effects of GH.
Sustained GH hypersecretion as seen in acromegaly induces a hypermetabolic state characterized by elevated IGF-I activity concomitantly with lipolysis, which induces fatty-acid dependent insulin resistance in muscle and fat. This monogenic and reversible form of insulin resistance is unrelated to the metabolic syndrome since the phenotype is lean.
The presentation will focus on the molecular mechanisms underpinning GH-induced insulin resistance in human models.
25 May 2021, 14:00-15:00 CET
Join Zoom Meeting: https://ucph-ku.zoom.us/j/63562594747
Meeting ID: 635 6259 4747
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