PhD students participating in August Krogh seminars receive 0,2 ECTS per seminar
AKC online seminar: Exploring the potential for mitochondrial-therapeutics to treat muscle weakness in Duchenne muscular dystrophy
August Krogh Club online seminar
Associate Professor Christopher Perry
York University in Canada.
There is an urgent unmet need to develop new therapies to treat muscle weakness in Duchenne Muscular Dystrophy. Current standard of care with glucocorticoids improves mobility, respiratory and cardiac functions, but there remains a substantial weakness and fibrosis in limb and respiratory muscle as well as the heart.
While the future of genetic therapies that correct or compensate for the genetic mutation hold promise, there will likely be a need for combining other treatments that target secondary contributors. Clinical practice will benefit from additional treatments informed by new research on other mechanisms causing muscle weakness.
In this light, mitochondrial dysfunction may contribute to an energetic collapse and oxidative stress that weakens dystrophic muscles even further. Our recent findings demonstrate a potential for improving muscle health in Duchenne by targeting and rescuing mitochondrial function.
12 March 2021, 15:00-16:00 CET
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