Double seminar: Regulation of muscle metabolism during and following exercise v/ Niels Ørtenblad

August Krogh Club Double Seminar

14:00-15:00: Greg Cartee: "Muscle Fiber Type-selective Effects of Exercise on Phosphorylation of Key Signaling Proteins and Insulinstimulated Glucose Uptake”
15:00-16:00: Niels Ørtenblad: ”Metabolic control in the genesis of fatigue”
16:00-17:00: Post seminar servings and socializing.

Metabolic control in the genesis of fatigue

v/ Professor Niels Ørtenblad, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Denmark.


Skeletal muscle is faced with challenging problems related to metabolic regulation during exercise, where energy turnover nearly instantly increases dramatically. Intriguingly, the components of skeletal muscle fibers are highly organized in terms of localization and within this organization glycogen, lipid droplets and mitochondria are found in distinct locations.

Recent studies have shown that the distribution of the metabolites is influenced by several factors as muscle work, obesity and disuse and that the different localizations of the stores are related to distinct processes in skeletal muscle function. Specifically, the sequence of complex steps in the muscle excitation-contraction coupling are either directly or indirectly dependent on the energy level of the muscle fiber and are affected by compartmentalized energy status. Thus, we have demonstrated that glycogen influences both muscle contractility and fatigability, through mechanisms involving basic ion regulation.

Research Profile

Niels Ørtenblad (NØ) is Professor and head of the Muscle Physiology and Biomechanics Research Unit at the Department of Sports Science and Clinical Biomechanics, University of Southern Denmark as well as Adjunct Professor at the Australian Catholic University, Melbourne, and Department of Health Sciences, Swedish Winter Sports Research Centre, Mid Sweden University.

His research has been focused on the role of energy turn-over in cell function, with special emphasis on the muscle cell. He attempts to use research models from the integrated whole body to the organelle and protein level. The key research goal is to elucidate the complex interaction between metabolic mechanisms and control of normal muscle function and identify key mechanisms regulating muscle fatigue in different target groups including ageing. A better understanding of these mechanisms is a key step towards the development of well targeted health policies aimed at delaying muscle impairment and disability.


Muscle glycogen and cell function – Location, location, location. Ørtenblad N, Nielsen J.

Muscle glycogen stores and fatigue. Niels Ørtenblad, Håkan Westerblad and Joachim Nielsen.

Lactate per se improves the excitability of depolarized rat skeletal muscle by reducing the Cl− conductance. Frank Vincenzo de Paoli, Niels Ørtenblad, Thomas Holm Pedersen, Rasmus Jørgensen and Ole Bækgaard Nielsen. 


Auditorium 1, August Krogh Building, Universitetsparken 13, DK-2100 Copenhagen


Participation is free, but please register here.

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