Double seminar: Regulation of muscle metabolism during and following exercise v/ Greg Cartee

August Krogh Club Double Seminar

14:00-15:00: Greg Cartee: "Muscle Fiber Type-selective Effects of Exercise on Phosphorylation of Key Signaling Proteins and Insulinstimulated Glucose Uptake”
15:00-16:00: Niels Ørtenblad: ”Metabolic control in the genesis of fatigue”
16:00-17:00: Post seminar servings and socializing.

Muscle Fiber Type-selective Effects of Exercise on Phosphorylation of Key Signaling Proteins and Insulinstimulated Glucose Uptake

v/ Greg Cartee, Professor and Associate Dean for Research, School of Kinesiology, Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.

Abstract

One exercise session can increase subsequent insulin-stimulated glucose uptake by skeletal muscle for several hours via mechanisms that remain to be completely elucidated. By definition, glucose uptake is a cellular process, so to fully understand exercise effects on muscle glucose uptake, it is necessary to understand glucose uptake at the cellular level. 

Accordingly, we developed and validated the first method that enables glucose uptake and muscle fiber type measurement in individual muscle fibers. Using this method, we have evaluated exercise-induced fiber type-specific effects on insulin-stimulated glucose uptake in rat skeletal muscle. We also recently performed fiber type-specific measurements of several important signaling proteins in skeletal muscle from exercised rats. I will present results from these studies and others to provide a unique perspective about exercise effects on insulin sensitivity.

Publications

Mechanisms for greater insulin-stimulated glucose uptake in normal and insulin-resistant skeletal muscle after acute exercise.  Am J Physiol Endocrinol Metab. 2015 Dec 15;309(12):E949-59. Cartee GD. DOI:  10.1152/ajpendo.00416.2015

Novel single skeletal muscle fiber analysis reveals a fiber type-selective effect of acute exercise on glucose uptake. Am J Physiol Endocrinol Metab. 2016 Nov 1;311(5):E818-E824. Cartee GD, Arias EB, Yu CS, Pataky MW. DOI: 10.1152/ajpendo.00289.2016

Fiber type-selective exercise effects on AS160 phosphorylation. Am J Physiol Endocrinol Metab. 2019 May 1;316(5):E837-E851. Wang H, Arias EB, Oki K, Pataky MW, Almallouhi JA, Cartee GD. DOI: 10.1152/ajpendo.00528.2018

Research Profile

Greg Cartee is a Professor and the Associate Dean for Research in the School of Kinesiology and a Professor in the Department of Molecular & Integrative Physiology at the University of Michigan. His research is focused on understanding mechanisms that regulate insulin-stimulated glucose uptake in skeletal muscle, especially in response to exercise and/or dietary interventions (calorie restriction or high fat diets). He uses rodent models to assess skeletal muscle glucose uptake and metabolism in the whole animal, isolated muscle tissue preparations, and single muscle fibers.

His research has been continuously supported by funding from the National Institutes of Health as a principal investigator since 1992. He frequently reviews grants for various funding agencies, including the National Institutes of Health, American Diabetes Association, Diabetes UK, German Research Foundation, Welcome Trust UK, and Dutch Diabetes Research Foundation.

Venue

Auditorium 1, August Krogh Building, Universitetsparken 13, DK-2100 Copenhagen

Registration

Participation is free, but please register here.

For PhD students

PhD students participating in August Krogh seminars receive 0,2 ECTS per seminar

Contact

Jonas Møller Kristensen, jmkristensen@nexs.ku.dk 

Upcoming seminars

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