AKC seminar: Proteostasis at Stake: Unveiling Obesity's Impact on Skeletal Muscle Protein Dynamics

Christos KatsanosAugust Krogh Seminar

Associate Professor Christos Katsanos

Associate Professor, School of Life Sciences, Arizona State University.

Adjunct Faculty, Department of Physiology and Biomedical Engineering, Mayo Clinic.

Director, Human Obesity Metabolism Laboratory.

Director, Biology PhD Program, School of Life Sciences, Arizona State University.


Maintaining proteostasis in skeletal muscle is important for muscle quality and has implications for health and disease. The synthesis rate of the many proteins found in skeletal muscle, including contractile proteins and proteins regulating substrate metabolism, is important for maintaining muscle proteostasis.

The seminar will discuss our current understanding of protein metabolism in skeletal muscle of humans with obesity. I will present evidence showing that obesity reduces protein synthesis at the whole-muscle level, as well as in distinct muscle protein pools (i.e., myofibrillar, mitochondrial proteins) and at the level of individual muscle proteins, with implications for altering the muscle proteome, and impacting both content and function of muscle proteins.

I will discuss biological mechanisms that may impair protein synthesis in muscle of humans with obesity, and present data on the effects of nutrients and exercise on muscle protein synthesis in these individuals. The seminar will conclude with suggestions for future research directions that can advance our understanding of the proteome turnover in muscle of humans with obesity.

Research Profile

Christos Katsanos is an Exercise Physiologist. He obtained his PhD from Florida State University, and he is currently an Associate Professor in the School of Life Sciences at Arizona State University, and Adjunct Faculty at Mayo Clinic - Arizona. He is the Director of the Human Obesity Metabolism (HOMe) Laboratory and the Biology PhD program at Arizona State University. He is a Fellow of the American Physiological Society and the American College of Sports Medicine.

His laboratory employs stable isotope tracers, mass spectrometry, and molecular biology methodologies to investigate substrate metabolism in health and disease. Current focus of the laboratory is on characterizing protein metabolism and fiber phenotype in skeletal muscle of humans with obesity. In addition to investigating mechanisms that sustain impaired metabolism in the muscle of humans with obesity, his laboratory studies the roles of exercise and dietary interventions in improving metabolic responses in the muscle of these individuals.





26 April 2024

14:00-15:00: Seminar and discussion
15:00-16:00: Post seminar servings and socializing


Auditorium 1, August Krogh Building, Universitetsparken 13, DK-2100 Copenhagen


Participation is free, but please register here.

For PhD students

PhD students participating in August Krogh seminars receive 0,2 ECTS per seminar


Kate Aiko Wickham, kawi@nexs.ku.dk 

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