PhD students participating in August Krogh seminars receive 0,2 ECTS per seminar
AKC seminar: Metabolic alterations in MASLD: lipids but also glucose
August Krogh Seminar
Amalia Gastaldelli
Research Director of Cardiometabolic Risk Unit at the Institute of Clinical Physiology, CNR, Pisa Italy.
Professor of Medicine-adjunct, UT Health at San Antonio, TX, USA.
Professor-Adjunct Scuola Superiore Sant'Anna, Pisa, Italy.
Abstract
The liver is central in regulating glucose homeostasis, being the major contributor to circulating lipids (mainly lipoproteins) and to endogenous glucose production. It is both a target and regulator of the action of regulatory hormones. Hepatic metabolic functions are altered in and contribute to the highly prevalent steatotic liver disease (SLD), including metabolic dysfunction-associated SLD (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH).
In this presentation I will discuss both the dysregulation of hepatic lipid and glucose metabolism in MASLD and MASH and associated metabolic comorbidities. A deep understanding of how MASLD affects lipid and glucose metabolic fluxes and regulatory hormones might assist in the early identification of at-risk individuals and the use or development of targeted therapies.
Literature
https://doi.org/10.1038/s41575-023-00888-8
https://doi.org/10.1016/j.jhepr.2024.101185
Research Profile
Amalia Gastaldelli, PhD, is a Research Director at the Institute of Clinical Physiology (IFC) of the National Research Council (CNR) in Pisa, Italy, where she heads the Cardiometabolic Risk Group and the Multi-Omics Mass Spectrometry Laboratory. She is also Adjunct Professor of Medicine at the Diabetes Division of the University of Texas Health, in San Antonio, TX, USA, and Affiliate Professor at the Institute of Life Sciences of the Sant'Anna School of Advanced Studies in Pisa.
Dr Gastaldelli's research focuses on the pathophysiological mechanisms of metabolic diseases (mainly Metabolic dysfunction Associated Steatotic Liver Disease (MASLD), Obesity and Type 2 Diabetes) with particular focus on the alteration of metabolic fluxes and hormone secretion and action. She leads a multidisciplinary group (biologists, chemists, mathematician) who use state of the art techniques for a translational approach to the study of human physiology, e.g., mass spectrometry coupled with stable isotope tracers for the evaluation in vivo of glucose and lipids production and disposal, insulin resistance and insulin secretion; omics techniques as metabolomics, lipidomics, fluxomics and exposomics; imaging tools as MRI, CT and US to study body fat distribution (visceral, hepatic, cardiac, muscular) and cardiac function and PET to study organ metabolism in collaboration with many institutions in Europe and United States.
She is currently President of the European MASLD Study Group affiliated to the EASD, which she founded in 2012 and provides a joint forum for diabetologists and hepatologists to explore the diagnosis, pathogenesis and treatment of MASLD and MASH and since 2018 she is President of the EGIR (European Group for the study of Insulin Resistance) Study Group also affiliated to the EASD. From 2010 to 2020 she chaired the European Chapter of the American College of Nutrition (ECACN) and was a member of the Board of Directors of the American College of Nutrition (ACN). In 2016 and 2023 she was part of the EASL-EASD-EASO committees (delegate of EASD) to write the European clinical guidelines for the management of NAFLD/MASLD.
Time
29 November 2024
13:00-14:00: Seminar and discussion
14:00-15:30: Post seminar servings and socializing
Venue
Auditorium 1, August Krogh Building, Universitetsparken 13, DK-2100 Copenhagen
Registration
Participation is free, but please register here.
For PhD students
PhD students participating in August Krogh seminars receive 0,2 ECTS per seminar
Contact
Kate Aiko Wickham, kawi@nexs.ku.dk
