PhD students participating in August Krogh seminars receive 0,2 ECTS per seminar
AKC Seminar: The roles of myokines in exercise as medicine – a translational perspective
August Krogh Club Seminar
Professor Bente Klarlund Pedersen, MD., PhD,
TrygFondens Center for Aktiv Sundhed (Centre for Physical Activity Research), University of Copenhagen, Denmark.
Time
29 March 2019
14:00-15:00: Seminar and discussion
15:00-16:00: Post seminar servings and socializing
Abstract
Skeletal muscle works as a secretory organ with the capacity to produce hundreds of myokines. This finding provides a conceptual basis for understanding how muscles communicate with other organs such as adipose tissue, liver, pancreas, bones, and brain. Recent advances suggest that myokines play a role in role in tumor defense and that some myokines pass the blood-brain barrier to enhance BDNF and hence hippocampal neurogenesis and learning.
The prototype myokine IL-6 is produced by contracting muscles and secreted into the circulation. Recent advances in understanding the physiological and biological roles of IL-6 demonstrate that IL-6 contributes to the regulation of glucose homeostasis in humans by affecting gastric emptying. Moreover, IL-6 seems to play a central role in regulating visceral adipose tissue mass in humans. Finally, IL-6 plays a role in directing natural killer cells to the tumor site during exercise and thereby appears to be involved in mediating exercise-induced anti-cancer effects.
References
Pedersen BK. The Physiology of Optimizing Health with a Focus on Exercise as Medicine. Annual review of physiology. 2018;81:607-27.
Hojman P, Gehl J, Christensen JF, Pedersen BK. Molecular Mechanisms Linking Exercise to Cancer Prevention and Treatment. Cell Metab. 2018;27(1):10-21.
Pedersen BK. Physical activity and muscle–brain crosstalk. Nature Review Endocrinology. 2019; In press.
Wedell-Neergaard AS, Lang Lehrskov L, Christensen RH, Legaard GE, Dorph E, Larsen MK, et al. Exercise-Induced Changes in Visceral Adipose Tissue Mass Are Regulated by IL-6 Signaling: A Randomized Controlled Trial. Cell Metab. 2018;[Epub ahead of print].
Lang Lehrskov L, Lyngbaek MP, Soederlund L, Legaard GE, Ehses JA, Heywood SE, et al. Interleukin-6 Delays Gastric Emptying in Humans with Direct Effects on Glycemic Control. Cell Metab. 2018;27(6):1201-11.
Venue
Auditorium 1, August Krogh Building, Universitetsparken 13, DK-2100 Copenhagen
Registration
Participation is free, but please register here.
For PhD students
PhD students participating in August Krogh seminars receive 0,2 ECTS per seminar
Contact
Jonas Møller Kristensen, jmkristensen@nexs.ku.dk
