PhD students participating in August Krogh seminars receive 0,2 ECTS per seminar
AKC / CWS mini symposium: Dissecting the pathophysiology and genetics of type 2 diabetes and obesity with polygenic mouse models
August Krogh / CWS mini symposium
Professor Hadi Al-Hasani
13:00-13:55: Professor Hadi Al-Hasani
13:55-14:25: Dr. Benjamin L. Parker, PhD
Short break
14:30-15:00: Dr. Adam Rose, PhD
15:00-15:55: Professor Mark Febbraio
16:00-17:00: Reception for all participants
Dissecting the pathophysiology and genetics of type 2 diabetes and obesity with polygenic mouse models
v/ Professor Hadi Al-Hasani, Director, Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Leibniz-Center for Diabetes Research at the Heinrich-Heine-University, Düsseldorf, Germany.
Abstract
Experimental mouse genetics represents a powerful tool for analyzing complex gene/ gene and gene/environment interactions in metabolic diseases. Polygenic mouse models reflect the complexity of human metabolic diseases sufficiently well. They are particularly suitable to analyze pathophysiological molecular mechanisms as well as interactions of genetic factors with the environment. We recently generated outbred populations from parental strains that strongly differ in their insulin sensitivity and their risk for developing type 2 diabetes (e.g. NZO, 129P2, C3H, SJL). Several genetic loci for diabetes-related traits were identified by linkage analysis and characterization of recombinant congenic lines (RCS). Molecular analysis of candidate genes, in particular the RabGAP Tbc1d1 has provided novel insights into the regulation of glucose and lipid metabolism.
Relevant papers
-
Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity. Chadt A, Leicht K, Deshmukh A, Jiang LQ, Scherneck S, Bernhardt U, Dreja T, Vogel H, Schmolz K, Kluge R, Zierath JR, Hultschig C, Hoeben RC, Schurmann A, Joost HG, Al-Hasani H. Nature genetics. 2008;40:1354-1359
-
Deletion of both rab-gtpase-activating proteins Tbc1d1 and Tbc1d4 in mice eliminates insulin- and aicar- stimulated glucose transport. Chadt A, Immisch A, de Wendt C, Springer C, Zhou Z, Stermann T, Holman GD, Loffing-Cueni D, Loffing J, Joost HG, Al-Hasani H. Diabetes. 2015 Mar;64(3):746-59
Research profile
My research interests have been identifying and characterizing susceptibility genes and patho-mechanisms for insulin resistance and type 2 diabetes by using experimental mouse genetics, and investigating insulin action, in particular glucose uptake and metabolism in adipose cells and skeletal muscle. Recently, our group has established a critical role of RabGAPs in both insulin- and contraction-induced glucose uptake in skeletal muscle, and the respective mechanisms are being further investigated in vivo and in vitro using biochemical and cell biology methods.
Time
19 May 2017
13:00-13:55: Professor Hadi Al-Hasani
13:55-14:25: PhD Benjamin L. Parker
Short break
14:30-15:00: PhD Adam Rose
15:00-15:55: Professor Mark Febbraio
16:00-17:00: Reception for all participants
Venue
Auditorium 1, August Krogh Building, Universitetsparken 13, DK-2100 Copenhagen
Registration
Participation is free, but please register here.
For PhD students
PhD students participating in August Krogh seminars receive 0,2 ECTS per seminar
Contact
Jonas Møller Kristensen, jmkristensen@nexs.ku.dk, mobile +45 6092 1309