August Krogh Seminar

Purinergic signalling: pathophysiology and therapeutic potential

v/ Professor Geoffrey Burnstock, Autonomic Neuroscience Centre, University College Medical School, Royal Free Campus, UK and Department of Pharmacology, The University of Melbourne, Australia

Abstract

The talk will start with a summary of the discovery and main conceptual steps involved in our current understanding of purinergic signalling, including the metabolism of extracellular nucleotides and nucleosides.

There is increasing interest in the pathophysiology of purinergic signalling and its therapeutic potential. The cotransmitter role of ATP appears to increase in pathological conditions, as in parasympathetic nerve control of human bladder in interstitial cystitis, obstructed and neurogenic bladder and in sympathetic nerve control of blood vessels in spontaneously hypertensive rats.

Clopidogrel, a P2Y12 receptor antagonist, has been very successful for the treatment of stroke and thrombosis, making 7.09 billion dollars worldwide in 2011. There is current exploration of P2X3, P2X2/3, P2X4 and P2X7 receptor antagonists for the treatment of pain. A P2Y2 receptor agonist was successfully developed for the treatment of dry eye, approved for use in Japan. Purinergic therapeutic strategies are being explored for kidney failure, inflammatory bowel disease, osteoporosis, cough, IVF, disorders of the central nervous system and cancer.

Time

11 October 2013

15:15-16:15: Seminar and discussion
16:15-16:45: Post seminar servings and socializing

Venue

Auditorium 1, August Krogh Building, Universitetsparken 13, DK-2100 Copenhagen

Registration

Participation is free, but please register here.

For PhD students

PhD students participating in August Krogh seminars receive 0,2 ECTS per seminar

Contact

Christian Frøsig, CFrosig@ifi.ku.dk, mobile +45 2875 1617

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