August Krogh Seminar

Do epigenetics modifications influence the pathogenesis of type 2 diabetes?

v/ Charlotte Ling, PhD, Associate Professor, Epigenetics and Diabetes Unit, Lund University Diabetes Centre, Department of Clinical Sciences, CRC, Scania University Hospital, Malmö, Sweden

Abstract

It is well established that combinations of genetic and environmental factors affect the susceptibility for type 2 diabetes. While ageing, obesity and physical inactivity represent non-genetic risk factors, genome-wide association studies have identified approximately 60 polymorphisms that influence type 2 diabetes. However, epigenetic modifications may also promote the disease.

Indeed, studies from our group suggest that epigenetic modifications are involved in the pathogenesis of type 2 diabetes. We have also shown that environmental factors, including exercise and diet, may affect the epigenetic pattern in human muscle and fat.

Moreover, we recently demonstrated that polymorphisms associated with type 2 diabetes directly modify the epigenetic pattern in humans. Together, we propose a model where combinations of genetic, epigenetic and non-genetic factors contribute to the risk of type 2 diabetes.

Time

22 March 2013 14:00-15:30

Venue

Auditorium 1, August Krogh Building, Universitetsparken 13, DK-2100 Copenhagen

Registration

Participation is free, but please register here.

For PhD students

PhD students participating in August Krogh seminars receive 0,2 ECTS per seminar

Contact

Christian Frøsig, CFrosig@ifi.ku.dk, mobile +45 2875 1617 

Upcoming seminars

Link to other upcoming seminars.