PhD students participating in August Krogh seminars receive 0,2 ECTS per seminar
AKC Seminar: Do epigenetics modifications influence the pathogenesis of type 2 diabetes?
August Krogh Club Seminar
Associate Professor Charlotte Ling, PhD
Epigenetics and Diabetes Unit, Lund University Diabetes Centre, Department of Clinical Sciences, CRC, Scania University Hospital, Malmö, Sweden.
Abstract
It is well established that combinations of genetic and environmental factors affect the susceptibility for type 2 diabetes. While ageing, obesity and physical inactivity represent non-genetic risk factors, genome-wide association studies have identified approximately 60 polymorphisms that influence type 2 diabetes. However, epigenetic modifications may also promote the disease.
Indeed, studies from our group suggest that epigenetic modifications are involved in the pathogenesis of type 2 diabetes. We have also shown that environmental factors, including exercise and diet, may affect the epigenetic pattern in human muscle and fat.
Moreover, we recently demonstrated that polymorphisms associated with type 2 diabetes directly modify the epigenetic pattern in humans. Together, we propose a model where combinations of genetic, epigenetic and non-genetic factors contribute to the risk of type 2 diabetes.
Time
22 March 2013 14:00-15:30
Venue
Auditorium 1, August Krogh Building, Universitetsparken 13, DK-2100 Copenhagen
Registration
Participation is free, but please register here.
For PhD students
PhD students participating in August Krogh seminars receive 0,2 ECTS per seminar
Contact
Christian Frøsig, CFrosig@ifi.ku.dk, mobile +45 2875 1617