August Krogh Seminar

Linking mitochondrial bioenergetics to the regulation of insulin sensitivity via redox systems biology

v/ P. Darrell Neufer, Director at East Carolina Diabetes and Obesity Institute, Departments of Physiology and Kinesiology, Brody School of Medicine, East Carolina University, USA.

 

Abstract

Chronic overnutrition and physical inactivity are major risk factors for insulin resistance and type 2 diabetes.

Recent research indicates that overnutrition generates an increase in hydrogen peroxide (H2O2) emission from mitochondria, serving as a release valve to relieve the reducing pressure created by fuel overload. H2O2 is a major input to cellular redox circuits that link to cysteine residues throughout the entire proteome to regulate cell function.

New data will be presented on the interplay between the PDH Complex and regulation of the cellular redox environment.

Finally, new insight will be offered as to how H2O2 emission may be linked via redox biology to the etiology of insulin resistance.

Time

28 September 2012 15:15-16:45

Venue

Auditorium 1, August Krogh Building, Universitetsparken 13, DK-2100 Copenhagen

Registration

Participation is free, but please register here.

For PhD students

PhD students participating in August Krogh seminars receive 0,2 ECTS per seminar

Contact

Christian Frøsig, CFrosig@ifi.ku.dk, mobile +45 2875 1617 

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