PhD students participating in August Krogh seminars receive 0,2 ECTS per seminar
AKC / CWS Seminar: Unleashing the therapeutic potential of mTORC1 inhibition for age-related diseases
August Krogh Club Seminar
Dr. Dudley W. Lamming
Department of Medicine, University of Wisconsin-Madison, USA.
Abstract
Age-related diseases are the major cause of morbidity and mortality in Western society. Recently, inhibition of the mTOR (mechanistic Target Of Rapamycin) signaling pathway by the FDA-approved drug rapamycin has been shown to promote lifespan and delay age-related diseases in model organisms including mice. Unfortunately, rapamycin has serious side effects in humans, including immunosuppression and glucose intolerance, which likely preclude the long-term prophylactic use of rapamycin as a therapy for age-related diseases.
Our work suggests that while the beneficial effects of rapamycin are largely mediated by inhibition of mTOR complex 1 (mTORC1), many of the negative side effects are mediated by “off-target” inhibition of a second mTOR-containing complex, mTORC2. We will discuss our recent work on strategies to more specifically inhibit mTORC1.
Relevant papers
- Lamming DW, Ye L, Sabatini DM, Baur JA. Rapalogs and mTOR inhibitors as anti-aging therapeutics. J Clin Invest. 2013; 123(3):980-9. Epub 2013/03/05. doi: 10.1172/JCI64099. PubMed PMID: 23454761; PubMed Central PMCID: PMC3582126.
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Lamming DW#, Mihayalova MM, Katajisto P, Baar EL, Yilmaz OH, Hutchins A, Gultekin Y, Gaither R, Sabatini DM#. Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan. Aging Cell 2014: doi: 10.1111/acel.12256; PubMed PMID: 25059582; PubMed Central PMCID: PMC4172536.
Research profile
Dr. Lamming is an Assistant Professor of Medicine and Endocrinology at the University of Wisconsin-Madison, where he is also co-director of the UW-Madison Department of Medicine Mouse Metabolic Phenotyping Platform.
Dr. Lamming is primarily focused on understanding the regulation of aging and metabolism by nutrient signaling pathways. The Lamming laboratory is currently investigating the physiological role played by the mechanistic target of rapamycin (mTOR), a protein kinase that, through a diverse set of substrates, regulates cellular processes including growth, metabolism, and aging.
Time
9 April 2015
14:00-15:00: Seminar and discussion
15:00-15:30: Post seminar servings and socializing
Venue
Auditorium 1, August Krogh Building, Universitetsparken 13, DK-2100 Copenhagen
Registration
Participation is free, but please register here.
For PhD students
PhD students participating in August Krogh seminars receive 0,2 ECTS per seminar
Contact
Christian Frøsig, CFrosig@nexs.ku.dk, mobile +45 2875 1617
